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KMID : 1134820140430010067
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 1 p.67 ~ p.73
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Anticancer Effects of Cultivated Orostachys japonicus on Human Prostate Cancer Cells
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Won Yeong-Seon
Lee Ju-Hye
Kwon Soon-Jae
Ahn Dong-Uk
Shin Dong-Young
Seo Kwon-Il
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Abstract
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This study was performed to determine the anticancer effects of cultivated Orostachys japonicus (COJ) and wild Orostachys japonicus (WOJ) on primary human prostate cancer cells (RC-58T/h/SA#4 cells). The morphology of cells treated with COJ and WOJ was distorted to shrunken cell masses. In addition, cell death induced by COJ and WOJ was associated with increased population of cells in sub-G1 phase as well as the formation of apoptotic bodies and nuclear condensation. COD and WOJ markedly reduced the number of viable prostate cancer cells in a dose-dependent manner, and cell numbers were lower than control cells. COJ and WOJ also inhibited increases in cell proliferation induced by environmental hormones such as dioxin and bisphenol A in charcoal-treated FBS (cFBS) medium. COJ and WOJ methanol extracts at the tested concentrations (150, 300, and 600 μg/mL) also dose-dependently inhibited cell proliferation induced by environmental hormones. These results indicate that COJ and WOJ exert anticancer effects on primary human prostate cancer cells.
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KEYWORD
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cultivated Orostachys japonicus, anticancer activity, apoptosis, environmental hormone
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